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Marburg Virus 1967
About Marburg Virus 1967
Marburg virus disease was first recognized in 1967 when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia, developed a severe hemorrhagic fever after handling African green monkey tissues imported from Uganda. There were 31 cases and 7 deaths. The virus, named after the German city, is a filovirus related to Ebola. The natural reservoir is the Egyptian fruit bat Rousettus aegyptiacus. Marburg virus has a case fatality rate of 24 to 88 percent depending on the outbreak and medical care. The largest Marburg outbreak occurred in Angola in 2004 to 2005, with 252 cases and 227 deaths. In 2023, Marburg outbreaks occurred in Equatorial Guinea and Tanzania, followed by Rwanda in 2024. Several experimental Marburg vaccines have been evaluated in clinical trials. Marburg virus research has been hampered by the rarity of outbreaks and the need for maximum containment BSL 4 laboratories.
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