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Pre-1500
5 entries
Black Death 1347
The Black Death was a bubonic plague pandemic caused by Yersinia pestis that killed an estimated 75 to 200 million peopl...
Plague of Justinian 541
The Plague of Justinian was the first recorded pandemic of bubonic plague, beginning in 541 AD in the Byzantine Empire d...
Antonine Plague 165
The Antonine Plague devastated the Roman Empire from 165 to 180 AD during the reign of Marcus Aurelius. The disease, lik...
Plague of Athens 430
The Plague of Athens struck the city state of Athens in 430 to 426 BC during the Peloponnesian War. The disease entered ...
Plague Cyprian 249
The Plague of Cyprian was a pandemic that struck the Roman Empire from approximately 249 to 262 AD during the reign of E...